The intersection of Queensway and Patricia Boulevard is scheduled to reopen on Thursday, the city says.
The stretch has been closed since Nov. 7 to allow a sewer line to be installed along Patricia.
"There will continue to be minor traffic interruptions on Patricia for the next few weeks while work continues at the site," the city said.
The line, which extends along Lower Patricia to London Street, is now complete except for operations to tie the new line into the existing downtown sewer main.
This work will require further excavation on Seventh Avenue near city hall and will be done when weather permits this spring.
The east shoulder of Queensway has been temporarily paved to serve as a walkway connecting two sections of sidewalk. It will be replaced with curb and sidewalk in 2019.
Two other walkways - one connecting Patricia to Queensway and another running along the base of Connaught Hill - will be open, but will not be paved until the spring.
The new line was put in because the old one, which serves the downtown and industrial area east of Queensway, is at capacity.
It's also part of a larger project to upgrade aging infrastructure in the vicinity of city hall that is at capacity or at high risk of failure.
"The City of Prince George is extremely grateful for the patience of pedestrians and motorists while crews worked to complete this important operation," city hall added.